منابع مشابه
RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis
Disassembly of nucleosomes in which genomic DNA is packaged with histone regulates gene expression. However, the mechanisms underlying nucleosome disassembly for gene expression remain elusive. We show here that epidermal growth factor receptor activation results in the binding of the RNF8 forkhead-associated domain to pyruvate kinase M2-phosphorylated histone H3-T11, leading to K48-linked poly...
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Granulocyte-macrophage colony-stimulating factor (GM-CSF) and the related cytokines interleukin (IL)-3 and IL-5 regulate the production and functional activation of hematopoietic cells. GM-CSF acts on monocytes/macrophages and granulocytes, and several chronic inflammatory diseases and a number of haematological malignancies such as Juvenile myelomonocytic leukaemia (JMML) are associated with d...
متن کاملOncoprotein ubiquitylation
Many molecular events are terminated by rapid protein degradation via the ubiquitin–proteasome system. Most target proteins are recognized by E3 ubiquitin ligases, often after specific protein modifications, leading to their poly-ubiquitylation and subsequent degradation by the proteasome. One such ubiquitin ligase is Fbw7, a member of the F-box protein family that associates with Skp1, Cul1, a...
متن کاملA novel dileucine lysosomal-sorting-signal mediates intracellular EGF-receptor retention independently of protein ubiquitylation.
One of the main goals of this study was to understand the relationship between an epidermal growth factor (EGF) receptor dileucine (LL)-motif (679-LL) required for lysosomal sorting and the protein ubiquitin ligase CBL. We show that receptors containing 679-AA (di-alanine) substitutions that are defective for ligand-induced degradation nevertheless bind CBL and undergo reversible protein ubiqui...
متن کاملMammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II (pol II) by suppressing transient pausing of the pol II at many sites along the DNA. Elongin is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, which can form an isolable Elongin BC subcomplex. Here, we have shown that both the ubiquitylation and proteasomal degra...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2017
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2017.6